Xanax is contraindicated in an allergy to benzodiazepines, as well as in myasthenia gravis, angle-closure glaucoma, acute intoxication with alcohol, opioids, analgesics, sleeping pills and psychotropics, shock, coma. The drug is not prescribed in the case of chronic obstructive diseases of the respiratory system, severe forms of depression.
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Tranquilizer is prescribed for anxiety, neuroses, which are accompanied by a sense of anxiety, a sense of danger, tension, anxiety, insomnia, irritability, psychosomatic disorders. It is effective for neutralization of neurotic reactive-depressive, anxiety-depressive states, which are accompanied by a deterioration in mood, a decrease in interest in the surrounding reality, a decrease in appetite, panic disorders (both accompanied by phobias, and without them).
Xanax is an anxiolytic drug derived from triazole-benzodiazepine. It has a sedative, hypnotic, anticonvulsant, muscle relaxant effect. It has the ability to reduce the ability to excite the subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibit spinal polysynaptic reflexes.
Xanax has a pronounced anxiolytic effect-reduces emotional stress, reduces anxiety, fears. In addition, it has a mild hypnotic effect-reducing the period of immersion in sleep, increasing its duration, reduces the frequency of awakenings in the middle of sleep. The drug reduces the effect on the central nervous system stimuli (emotional, motor, vegetative), which interfere with the mechanism of falling asleep.
The active substance of Xanax is alprazolam with auxiliary components. The drug is available for sale in the tablet form. The use of Xanax during pregnancy and lactation is contradicted Xanax is toxic to the fetus, it increases the risk of developing a defect in the first trimester, causes dependence in the second, inhibits the development of the central nervous system in the third one. It enters breast milk.
The dosage of Xanax is selected individually. If it needs to be increased, then start with the evening dose, and then increase the day one. The initial dosage on average is 250-300 mg three times a day, the maximum permissible increase is up to 450 mg per day. The maintenance dose is from 500 to 750 mg per day.
The cancellation and reduction of Xanax dosage are carried out with a gradual decrease, you should not abruptly cancel the drug, because it can cause the so-called “withdrawal effect.” The dose is reduced by 500 mg after 3 days, or even more slowly. Overdose can cause depression of consciousness, weakness, bradycardia, drowsiness, respiratory distress, decreased reflexes, coma. You should take the sorbents as soon as possible to have the gastric lavage.
At the initial stage of Xanax treatment, there may be a feeling of drowsiness, disorientation, weakness, ataxia, tremor, myasthenia gravis, memory loss, the ability to think to concentrate, mood depression. In some cases, paradoxical reactions were observed-increased symptoms, for the relief of which, in fact, this drug is intended. Sometimes there was the appearance of tachycardia, lowering blood pressure. There are possible dyspeptic, allergic reactions.
If there is the simultaneous use of psychotropic, anticonvulsants, drugs, and ethanol, there is an increase in the oppressive effect of Xanax on the central nervous system.
The simultaneous use of histamine H2-receptor blockers reduces the clearance of Xanax and enhances the inhibitory effect of alprazolam on the central nervous system; the antibiotics from the group of macrolides reduce the clearance of Xanax.
The simultaneous use of hormonal contraceptives for oral administration increases the effect of Xanax.
If there is the simultaneous use of Xanax with dextropropoxyphene, there is a more pronounced CNS depression than in combination with other benzodiazepines, since it is possible to increase the concentration of alprazolam in blood plasma.
The simultaneous reception of Xanax with digoxin increases the risk of cardiac glycoside intoxication.
Xanax increases the plasma concentration of imipramine.
The simultaneous use of Itraconazole, ketoconazole enhances the effects of xanax.
If there is the simultaneous use of paroxetine, it is possible to increase the effects of alprazolam, due to the inhibition of its metabolism.
Fluvoxamine increases the plasma concentration of xanax and the risk of side effects.
The simultaneous use of fluoxetine causes an increase in the concentration of alprazolam in blood plasma, which is possible due to a decrease in its metabolism and clearance under the influence of fluoxetine, which is accompanied by psychomotor disorders.
It is impossible to exclude the possibility of strengthening the action of Xanax while using erythromycin.